YM-47522, a novel antifungal antibiotic produced by Bacillus sp. I. Taxonomy, fermentation, isolation and biological properties.
نویسندگان
چکیده
YM-47522, a novel antibiotic, was isolated from the culture broth of Bacillus sp. YL-03709B. The antibiotic was purified by centrifugal partition chromatography and ODS column chromatography. It exhibited potent in vitro antifungal activity especially against Rhodotorula acuta and Pichia angusta (MIC: 0.05 and 0.75 microgram/ml, respectively). It also showed moderate or weak antifungal activity against Candida albicans and Cryptococcus neoformans (MIC: 25 and 6.25 micrograms/ml, respectively), whereas it was inactive against filamentous fungi and bacteria.
منابع مشابه
YM-47522, a novel antifungal antibiotic produced by Bacillus sp. II. Structure and relative stereochemistry.
YM-47522 (1) was isolated from the fermentation broth of Bacillus sp. YL-03709B as an antifungal antibiotic. The structure of 1 was elucidated by spectroscopic analyses. YM-47522 (1) consisted of C13 carboxylic acid amide and cinnamate moieties. The relative stereochemistry was also proposed on the basis of chemical transformation into a 1,3-diol acetonide and its NMR data.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 49 4 شماره
صفحات -
تاریخ انتشار 1996